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Interleukin-1 cluster is associated with genetic risk for schizophrenia and bipolar disorder

¹ Unitat d’Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, Barcelona 08028, Spain
² Clínica Mental Santa Coloma, Barcelona, Spain
³ Centre de Salut Mental Esquerre de l’Eixample, Hospital Clínic i Provincial de Barcelona, and Institut d’Investigació Biomédica Agustí Pi i Sunyer (IDIBAPS), Barcelona, Spain

Correspondence to:
L Fañanás
Unitat d’Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona, Spain; sergi.papiol@ub.edu] Received 30 July 2003
16 November 2003

Abbreviations: BP, bipolar disorder; CI, confidence intervals; FH, family history; OR, odds ratio

The first 150 words of the full text of this article appear below.

Schizophrenia and affective psychoses are severe and prevalent psychiatric disorders described in all cultures and populations. Whether these functional psychoses are two distinct disorders, or are closely related in aetiology, has been debated in the literature during the last century.^1–4

Several studies have suggested that schizophrenia and bipolar disorder are on a continuum of liability. Psychopathological dimensions and psychiatric symptoms shared by both groups of patients would be compatible with this overlap.⁵ Likewise, other risk factors, such as cerebral ventricle enlargement,⁶ markers of prenatal suffering,⁷ or life events,⁸ have been described in both mental disorders. Recent molecular linkage studies have suggested the possible existence of shared disease loci for both disorders.⁹ Of special interest are the family studies showing that first degree relatives of bipolar patients have a three times increased risk for schizophrenia compared with first degree relatives of controls.^10,11 These data suggest the presence of a common genetic . . . [Full text of this article]