© 2003 BMJ Publishing Group
LETTER TO JMG
Gender specific association of aldosterone synthase gene polymorphism with renal survival in patients with IgA nephropathy
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
Correspondence to:
Correspondence to:
Dr I Narita, Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachi-dori, Niigata, 951-8510, Japan;
naritai@med.niigata-u.ac.jp
Keywords: gender; IgA nephropathy; aldosterone synthase; CYP11B2
| The first 150 words of the full text of this article appear below. |
Immunoglobulin A nephropathy (IgAN), which is the most prevalent form of primary glomerulonephritis and one of the major causes of end stage renal disease (ESRD), has a variable clinical course.1–3 Poor prognostic factors for the progression of renal dysfunction in IgAN have been identified as high blood pressure, heavy proteinuria, and a severe histopathological appearance of the renal biopsy.4,5 In addition to these prognostic factors, it has been proposed that several genetic backgrounds are associated with a susceptibility to ESRD in patients with IgAN.6,7
The renin-angiotensin-aldosterone system is an important regulator of blood pressure and plays a central role in the development and progression of end organ damage. Polymorphisms in genes that encode components of this system have been reported to be associated with physiological risk factors for progressive renal dysfunction in IgAN. The most consistent of these is the angiotensinogen (AGT) gene, which is associated with essential
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