LETTER TO JMG

Association of single nucleotide polymorphisms in the oxidised LDL receptor 1 (OLR1) gene in patients with acute myocardial infarction

R Mango¹, F Clementi¹, P Borgiani¹, G B Forleo¹, M Federici¹, G Contino¹, E Giardina¹, L Garza², I E Fahdi², R Lauro¹, J L Mehta², G Novelli¹, F Romeo¹

¹ Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Italy
² Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, USA

Correspondence to:
Correspondence to:
Giuseppe Novelli
Dipartimento di Biopatologia e Diagnostica per Immagini, Università di Roma "Tor Vergata", Via Montpellier 1 00133 Roma, Italy; novelli@med.uniroma2.it

Keywords: denaturing high performance liquid chromatography; myocardial infarction; OLR1/LOX 1; SNPs

Abbreviations: AMI, acute myocardial infarction; CAD, coronary artery disease; OLR1, oxidised LDL receptor 1; OR, odds ratio; oxLDL, oxidised LDL; SNP, single nucleotide polymorphism; TNF, tumour necrosis factor

The first 150 words of the full text of this article appear below.

Acute myocardial infarction (AMI) is a significant cause of mortality and morbidity. Substantial data support a plausible role for oxidised LDL (oxLDL) in the aetiology of this disease.^1,2 The human OLR1 (or LOX 1) gene encodes the endothelium derived lectin-like oxidised low density lipoprotein (oxLDL) receptor, which is involved in the binding, internalisation, and proteolytic degradation of oxLDL, suggesting that it may play a significant role in atherogenesis.³ OLR1 is considered a good candidate for atherosclerosis and AMI since it is induced in vitro by inflammatory cytokines and in vivo by pro-atherogenic conditions like hypertension, hyperlipidaemia, and diabetes mellitus.⁴ Recently, upregulation of OLR1 has been shown in ischaemia reperfusion injury in the rat.⁵ OLR1 acts as a mediator of "endothelial dysfunction" favouring superoxide generation, inhibiting nitric oxide production, and enhancing endothelial adhesiveness for monocytes.^6–8 It is noteworthy that the versatile activities of OLR1 also include the ability to bind not . . . [Full text of this article]

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