LETTER TO JMG

APOE and TGF-ß1 genes are associated with obesity phenotypes

J-R Long¹, P-Y Liu¹, Y-J Liu¹, Y Lu¹, D-H Xiong¹, L Elze¹, R R Recker¹, H-W Deng^1,2,3

¹ Osteoporosis Research Center, Creighton University, Omaha, NE, USA
² Department of Biomedical Sciences, Creighton University, Omaha, NE, USA
³ Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, Changsha, Hunan, P R China

Correspondence to:
Correspondence to:
Dr H-W Deng
Osteoporosis Research Center, Creighton University Medical Center, 601 N. 30th St. Suite 6787 Omaha, NE 68131; deng@creighton.edu

Keywords: APOE; obesity; TGF-ß1

Abbreviations: APOE, apolipoprotein E; BMI, body mass index; DXA, dual energy X-ray absorptiometry; IBD, identity by descent; LD, linkage disequilibrium; LDL, low density lipoprotein; PCR, polymerase chain reaction; PFM, percentage fat mass; QTDT, quantitative transmission disequilibrium test; SNP, single nucleotide polymorphism; TGF-ß1, transforming growth factor beta 1

The first 150 words of the full text of this article appear below.

Obesity, defined as a body mass index (BMI) of greater than 30 kg/m², has become a worldwide public health problem.¹ About 250 million adults, roughly 7% of the world adult population, are considered obese and two or three times as many may be overweight with BMI of 25–30 kg/m².² A recent analysis shows that the health care cost of obesity is probably between 0.89% and 4.32% of the national expenditure in the United States.³ Obesity is associated with many diseases such as type 2 diabetes mellitus, hypertension, coronary heart disease, and certain forms of cancer.¹ As a complex disease, obesity is determined by multiple genetic and environmental factors, including physiological, behavioural, and sociocultural factors.^4–7 Numerous molecular genetics studies have been launched to search for the genes underlying the variations of obesity phenotypes, resulting in a host of candidate genes and potentially important genomic regions.⁸

Apolipoprotein E (APOE), coding . . . [Full text of this article]

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