LETTER TO JMG

Localisation of the Y chromosome stature gene to a 700 kb interval in close proximity to the centromere

S Kirsch¹, B Weiss¹, S Kleiman², K Roberts³, J Pryor³, A Milunsky⁴, A Ferlin⁵, C Foresta⁵, G Matthijs⁶, G A Rappold¹

¹ Institute of Human Genetics, University of Heidelberg, INF 328, 69120 Heidelberg, Germany
² Institute for the Study of Fertility, Lis Maternity Hospital, Tel Aviv Sourasky Medical Centre, Tel Aviv 64239, Israel
³ Department of Urologic Surgery, University of Minnesota Medical School, Minneapolis, MN 55455, USA
⁴ Center for Human Genetics, Boston University School of Medicine, Boston, MA 02118, USA
⁵ Department of Medical and Surgical Sciences, Clinica Medica III, University of Padova, Via Ospedale 105, 35128 Padova, Italy
⁶ Center for Human Genetics, University of Leuven, Herestraat 49, 3000 Leuven, Belgium

Correspondence to:
Correspondence to:
Dr G A Rappold, Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany;
gudrun_rappold@med.uni-heidelberg.de

Keywords: Y chromosome; height; GCY gene

Abbreviations: BAC, bacterial artificial chromosome; PAC, P1 derived artificial chromosome; SFV, sequence family variants; STS, satellite type sequences; PAR, pseudoautosomal region

The first 150 words of the full text of this article appear below.

The sex related height difference in humans is thought to be caused mainly by two components: first, a hormonal component determined by the sex dimorphism of bioactive gonadal steroids, and, second, a genetic component attributed to a Y specific growth gene, GCY.^1–3 Despite extensive mapping attempts for this gene on the human Y chromosome,^4–7 its precise position remains unknown. We have recently provided evidence that inappropriate cytogenetic methodology in the characterisation of Y chromosomal terminal deletions has led to some of the difficulties in elucidating the GCY critical region. In order to circumvent these problems, we have decided to consider only patients presenting de novo interstitial deletions for GCY analysis on the Y chromosome.⁸ This approach allows the assignment of GCY to a particular chromosomal interval without excluding the presence of X0 mosaicism and/or i(Yp) and idic(Yq11) chromosomes in patients with terminal deletions. Indeed, the direct comparison of overlapping . . . [Full text of this article]

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