Electronic letters
Homoplasmic
3316G
A in the ND1 gene of the
mitochondrial genome: a pathogenic mutation or a neutral polymorphism?
| The first 150 words of the full text of this article appear below. |
EDITOR
We read with interest the article by
Odawara et al,1 in which the
authors reported that a homoplasmic mutation, 3316G
A, in the
ND1 gene of the mitochondrial genome was
associated with type 2 diabetes in the Japanese population. Recently,
we have performed the same study in the Chinese population and,
interestingly, we obtained a different result.
A total of 277 subjects with type 2 diabetes aged 29-85 years (mean
58.9 (SD 12.0) years) who attended the Diabetes Clinic of United
Christian Hospital, Hong Kong, were recruited into this study after
informed consent was obtained. The diagnosis was based on the
independent criteria of the World Health Organization: (1) a 75 g oral
glucose tolerance test with a two hour value of 11.0 mmol/l or more,
(2) a random plasma glucose of 11.0 mmol/l or more with typical
symptoms of diabetes, or (3) a fasting plasma glucose of 7.8 mmol/l or
more on more than one
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