EDITORIn 1994, we reported a 13 year old patient with 18p deletion and ulerythema ophryogenes and keratosis pilaris.¹ We then suggested that this observation may be helpful in future attempts to localise the gene defect responsible for follicular genokeratoses, even though similar skin lesions have been reported in a number of patients with various chromosomal disorders, including sex chromosome aneuploidies. Remarkably, in addition to the report by Horsley et al,² two further observations of this association were recently reported.^3 4 This confirmed the presence of a true association and prompted a further look into the material that we obtained from the biopsy of our patient,¹ searching for possible genes localised in the deletion area that may have a role in the pathogenesis of keratosis pilaris or ulerythema ophryogenes.

Indeed, the human laminin 1 chain is encoded by an approximately 9.5 kb mRNA transcribed from the LAMA1 gene, which is located on . . . [Full text of this article]