Letters to the editor
Thrombophilic polymorphisms in pre-eclampsia: altered frequency of the functional 98C>T polymorphism of glycoprotein IIIa
Kevin M O'Shaughnessya, Beiyuan Fua, Sarah Downinga, Nicholas H Morrisba Clinical
Pharmacology Unit, Department of Medicine, University of Cambridge
Clinical School, Cambridge,
UK, b Academic
Department of Obstetrics and Gynaecology, Chelsea and Westminster
Hospital and North London Hospitals Trust, London,
UK
Correspondence to: Dr O'Shaughnessy, Clinical Pharmacology Unit, Level 6 ACCI, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK, kmo22@medschl.cam.ac.uk
| The first 150 words of the full text of this article appear below. |
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Introduction |
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EDITOR
Pre-eclampsia is a heritable endothelial
disorder, which is unique to pregnancy1 and
characteristically associated with haemostatic and thrombophilic
abnormalities. This association has led to the identification of a
number of gene variants that might confer thrombophilic risk in
pre-eclampsia. An increased carrier rate for two of these
polymorphisms, factor V Leiden2 and the thermolabile
variant of methylenetetrahydrofolate reductase (MTHFR),3
has been reported in some women with pre-eclampsia. However, we have
been unable to replicate these findings in our own East Anglian
population.4
We have now looked at two further candidate thrombophilic polymorphisms
in our pre-eclampsia cohort that are involved in the regulation of
vascular thrombosis. The first is the 20210G>A polymorphism in the 3'
UTR region of the prothrombin (PT) gene that causes a modest rise in
plasma prothrombin levels,5 and is reportedly associated
with severe pre-eclampsia in an Israeli cohort.6 The
second is a coding variant (98C>T)
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