J Med Genet 1999;36:720-721 ( September )

Letters to the editor

Linkage analysis of 56 multiplex families excludes the Cowden disease gene PTEN as a major contributor to familial breast cancer

The first 150 words of the full text of this article appear below.

EDITORA number of genes are now known to be involved in inherited susceptibility to breast cancer. In the context of multiple case families, the most well identified and characterised genes are BRCA1 on 17q^1 2 and BRCA2 on 13q.^3 4 Both linkage and mutation studies indicate that these genes account for the large majority of families segregating both early age of onset breast cancer and ovarian cancer, and those with both male and female breast cancer cases. However, other studies^5-8 indicate that BRCA1 and BRCA2 account for less than half of site specific breast cancer families, suggesting that other major susceptibility genes may be important in this group. We therefore initiated a collaborative genomic search, using a large panel of female breast cancer only families in which germline mutations in the BRCA1 and BRCA2 coding sequence were not detected and in which there was no strong evidence of linkage to . . . [Full text of this article]

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