Journal of Medical Genetics 2009;46:451-454
SHORT REPORTS
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length
1 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
2 Department of Medicine, Jewish General Hospital, Faculty of Medicine, McGill University, Montréal, Québec, Canada
3 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK
4 Centre of Human Development and Aging, New Jersey Medical School, Newark, New Jersey, USA
5 Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
Professor T D Spector, Department of Twin Research & Genetic Epidemiology, King’s College London, St Thomas’ Hospital Campus, Lambeth Palace Road, London SE1 7EH, UK; tim.spector{at}kcl.ac.uk
Background: Telomere length is a predictor for a number of common age related diseases and is a heritable trait.
Methods and results: To identify new loci associated with mean leukocyte telomere length we conducted a genome wide association study of 314 075 single nucleotide polymorphisms (SNPs) and validated the results in a second cohort (n for both cohorts combined = 2790). We identified two novel associated variants (rs2162440, p = 2.6x10–6; and rs7235755, p = 5.5x10–6) on chromosome 18q12.2 in the same region as the VPS34/PIKC3C gene, which has been directly implicated in the pathway controlling telomere length variation in yeast.
Conclusion: These results provide new insights into the pathways regulating telomere homeostasis in humans.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
jmg.2008.064956v1
jmg.2008.064956v2
46/7/451 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
