Club foot, an adverse outcome of early amniocentesis: disruption or deformation?
S A Farrella, A M Summersb, L Dallairec, J Singerd, Jo-Ann M Johnsone, R D Wilsonf, members of CEMAT
a Division of
Genetics, Department of Laboratory Medicine, The Credit Valley
Hospital, 2200 Eglinton Avenue W, Mississauga, Ontario, Canada L5M 2N1, b Genetics Program, North York
General Hospital and IODE Children's Centre, North York, Ontario,
Canada M2K 1E1, c Service de
Genetique Medicale, Hopital Sainte-Justine, Centre Hospitalier
Universitaire Mere-Enfant, Montreal, Quebec, Canada, d Department
of Health Care and Epidemiology, University of British Columbia,
Vancouver, BC, Canada, e Department of Obstetrics and Gynecology, The
Toronto Hospital, Toronto, Ontario, Canada, f University of British Columbia Department of
Obstetrics and Gynecology, Children's and Women's Health Centre,
Vancouver, British Columbia, Canada
Correspondence to: Dr Farrell.
Revised version received 18 May 1999;
Accepted for publication 17 June
1999
An association between the occurrence of club foot and early
amniocentesis has been reported. The largest of these randomised studies was the Canadian Early and Mid-Trimester Amniocentesis Trial.
Data describing the neonatal outcome, focusing on this association, are
presented. Possible mechanisms for the association and the implications
for the development of club foot are discussed.
Keywords: amniocentesis; early amniocentesis; club foot
© 1999 by J Med Genet
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