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Journal of Medical Genetics, 1978, Vol 15, 352-356

ARTICLES

Familial atypical multiple mole-melanoma syndrome

HT Lynch, BC Frichot 3d and JF Lynch

A family is described showing concordance for malignant melanoma and a cutaneous phenotype characterised by multiple large moles of variable size and colour (reddish-brown to bright red) with pigmentary leakage. Transmission of the cutaneous phenotype in the subject family, and in several others currently under investigation, shows an inheritance pattern consistent with a simple autosomal dominant factor. This cutaneous phenotype signifying melanoma risk may now be added to an increasing body of knowledge dealing with cancer-related genodermatoses.




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