Colon cancer

Citations 1-10 of 102 total displayed.

Original articles
Mutation prediction models in Lynch syndrome: evaluation in a clinical genetic setting

D Ramsoekh, M E van Leerdam, A Wagner, E J Kuipers, E W Steyerberg
J. Med. Genet. 2009 46: 745 -751; published online before print as 10.1136/jmg.2009.066589 [Abstract] [Full text] [PDF] [Request Permissions]  

Original articles
Comparison of predictive models, clinical criteria and molecular tumour screening for the identification of patients with Lynch syndrome in a population-based cohort of colorectal cancer patients

J Balmaña, F Balaguer, S Castellví-Bel, E W Steyerberg, M Andreu, X Llor, R Jover, A Castells, S Syngal, for the Gastrointestinal Oncology Group of the Spanish Gastroenterological Association
J. Med. Genet. 2008 45: 557 -563; published online before print as 10.1136/jmg.2008.059311 [Abstract] [Full text] [PDF] [Request Permissions]  

Original articles
A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome

M Clendenning, L Senter, H Hampel, K Lagerstedt Robinson, S Sun, D Buchanan, M D Walsh, M Nilbert, J Green, J Potter, A Lindblom, A de la Chapelle
J. Med. Genet. 2008 45: 340 -345; published online before print as 10.1136/jmg.2007.056150 [Abstract] [Full text] [PDF] [Request Permissions]  

Letters to JMG
Direct contact in inviting high-risk members of hereditary colon cancer families to genetic counselling and DNA testing

K Aktan-Collan, A Haukkala, K Pylvänäinen, H J Järvinen, L A Aaltonen, P Peltomäki, E Rantanen, H Kääriäinen, J-P Mecklin
J. Med. Genet. 2007 44: 732 -738; published online before print as 10.1136/jmg.2007.051581 [Abstract] [Full text] [PDF] [Request Permissions]  

Short reports
Biallelic mutation of MSH2 in primary human cells is associated with sensitivity to irradiation and altered RAD51 foci kinetics

J Barwell, L Pangon, S Hodgson, A Georgiou, I Kesterton, T Slade, M Taylor, S J Payne, H Brinkman, J Smythe, N J Sebire, E Solomon, Z Docherty, R Camplejohn, T Homfray, J R Morris
J. Med. Genet. 2007 44: 516 -520; published online before print as 10.1136/jmg.2006.048660 [Abstract] [Full text] [PDF] [Request Permissions] [ web only figure ]  

Letters to JMG
Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP

Nirosha Suraweera, Andrew Latchford, Amy McCart, Pauline Rogers, Sarah Spain, Oliver Sieber, Robin Phillips, Ian Tomlinson, Andrew Silver
J. Med. Genet. 2007 44: 541 -544; published online before print as 10.1136/jmg.2007.049965 [Abstract] [Full text] [PDF] [Request Permissions]  

Letters to JMG
Cancer risks in carriers of the BRCA1/2 Ashkenazi founder mutations

Luna Kadouri, Ayala Hubert, Yakir Rotenberg, Tamar Hamburger, Michal Sagi, Chovav Nechushtan, Dvorah Abeliovich, Tamar Peretz
J. Med. Genet. 2007 44: 467 -471; published online before print as 10.1136/jmg.2006.048173 [Abstract] [Full text] [PDF] [Request Permissions]  

Letters to JMG
Should healthcare providers have a duty to warn family members of individuals with an HNPCC-causing mutation? A survey of patients from the Ontario Familial Colon Cancer Registry

Kelly Kohut, Michael Manno, Steven Gallinger, Mary Jane Esplen
J. Med. Genet. 2007; 44: 404-407. [Abstract] [Full text] [PDF] [Request Permissions]  

Letters to JMG
Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells

Hafid Alazzouzi, Gianpaolo Suriano, Angel Guerra, Alberto Plaja, Eloi Espín, Manel Armengol, Pia Alhopuro, Sergia Velho, Yasuhisa Shinomura, Juan José González-Aguilera, Hiroyuki Yamamoto, Lauri A Aaltonen, Víctor Moreno, Gabriel Capellà, Miguel Angel Peinado, Raquel Seruca, Diego Arango, Simó Schwartz, Jr
J. Med. Genet. 2007 44: 75 -80; published online before print as 10.1136/jmg.2006.042572 [Abstract] [Full text] [PDF] [Request Permissions]  

Letters to JMG
MDM2 SNP309 accelerates colorectal tumour formation in women

Gareth L Bond, Chiara Menin, Roberta Bertorelle, Pia Alhopuro, Lauri A Aaltonen, Arnold J Levine
J. Med. Genet. 2006 43: 950 -952; published online before print as 10.1136/jmg.2006.043539 [Abstract] [Full text] [PDF] [Request Permissions]